Contents

explanation=Predicts the toxicological hazard (when administered orally) from the molecular structure. <ul><li>Low (Class I) : Substances with simple chemical structures and for which efficient modes of metabolism exist,suggesting a low order of oral toxicity.<h6>Fifth percentile NOEL (mg/kg bw/day)  3.0 <br>Human exposure threshold  (mg/person/day)  1.8</h6><li>Intermediate (Class II) :Substances which possess structures that are less innocuous than class I substances, but do not contain structural features suggestive of toxicity like those substances in class III. <h6>Fifth percentile NOEL (mg/kg bw/day)  0.91<br> Human exposure threshold  (mg/person/day)  0.54</h6><li>High (Class III).Substances with chemical structures that permit no strong initial presumption of safety or may even suggest significant toxicity or have reactive functional groups.<h6>Fifth percentile NOEL (mg/kg bw/day)  0.15<br> Human exposure threshold  (mg/person/day)  0.09</h6></ul>
reference1=Cramer G. M., R. A. Ford, R. L. Hall, Estimation of Toxic Hazard - A Decision Tree Approach, J. Cosmet. Toxicol., Vol.16, pp. 255-276, Pergamon Press, 1978
reference2=I.C. Munro, R.A. Ford, E. Kennepohl, and J.G. Sprenger, Correlation of structural class with No-Observed-Effect Levels: A proposal for establishing a threshold of concern, Food Chem. Toxicol. 34 (1996), pp. 829-867.
reference3=Patlewicz G, Jeliazkova N, Safford RJ, Worth AP, Aleksiev B. (2008) An evaluation of the implementation of the Cramer classification scheme in the Toxtree software. SAR QSAR Environ Res. ;19(5-6):495-524.
uri=http://toxtree.sourceforge.net/cramer.html
vendor=Ideaconsult Ltd.
vendoruri=http://ideaconsult.net
priority=1
endpoint=Oral toxicity
trainingdata=https://toxtree.svn.sourceforge.net/svnroot/toxtree/trunk/toxtree/toxtree-plugins/toxtree-cramer/src/test/resources/Cramer/CramerRules.csv
testdata=https://toxtree.svn.sourceforge.net/svnroot/toxtree/trunk/toxtree/toxtree-plugins/toxtree-cramer/src/test/resources/Munro/munro-all.csv

Version data entries

1 entries across 1 versions & 1 rubygems

Version	Path
toxtree-0.0.1	Toxtree-v2.6.13/src/toxTree/tree/cramer/CramerRules.properties