aleph-publish:000870755

00523pM2.01200024------u 00523pM2.01200024------u MU HT013694492 HT013803972 20030611 20031006 20070216 20110505 HT013803972 967575699 292 HBZHT013803972 a|1uaz|z||||| DE eng a|a||||||||||| 61 6 292 464 468 60 60 2 2 Nicolaou, Kyriacos C. (DE-588)11391041X Sorensen, Erik J. 1966- (DE-588)172891523 Snyder, Scott A. (DE-588)124964087 Chen, Jason S. (DE-588)143527339 More targets, strategies, methods Classics in total synthesis K. C. Nicolaou and S. A. Snyder Weinheim [u.a.] VCH 1996 2003 XIX, 639 S. : Ill., graph. Darst. 1 CD-ROM (12 cm) Verlagsname später Wiley-VCH Erschienen Bd. [1] - 3 3-527-30684-6 Pb. : ca. EUR 59.00 (freier Pr.), CHF 87.00 3-527-30685-4 03,N23,1163 VK 5500 VK 5500 Organische Synthese (DE-588)4075695-6 Naturstoff (DE-588)4041418-8 Retrosynthese (DE-588)4330854-5 000870755 9783527306848 Organische Chemie Chemische Synthese (DE-588)4075695-6 Organische Chemie Chemische Synthese (DE-588)4075695-6 Nicolaou, Kyriacos (DE-588)11391041X Nicolaou, K. C. (DE-588)11391041X Nicolaou, K. (DE-588)11391041X Snyder, S. A. (DE-588)124964087 Chen, Jason (DE-588)143527339 Chen, J. S. (DE-588)143527339 Chen, J. (DE-588)143527339 Sorensen, E. J. 1966- (DE-588)172891523 Chen, Jason (DE-588)143527339 Chen, J. S. (DE-588)143527339 Chen, J. (DE-588)143527339 Sorensen, E. J. 1966- (DE-588)172891523 Nicolaou, Kyriacos (DE-588)11391041X Nicolaou, K. C. (DE-588)11391041X Nicolaou, K. (DE-588)11391041X Snyder, S. A. (DE-588)124964087 Nicolaou, Kyriacos (DE-588)11391041X Nicolaou, K. C. (DE-588)11391041X Nicolaou, K. (DE-588)11391041X Sorensen, E. J. 1966- (DE-588)172891523 Sorensen, E. J. 1966- (DE-588)172891523 Snyder, S. A. (DE-588)124964087 Chen, Jason (DE-588)143527339 Chen, J. S. (DE-588)143527339 Chen, J. (DE-588)143527339 Organische Chemie Chemische Synthese (DE-588)4075695-6 Retrosynthetische Analyse (DE-588)4330854-5 Retrosynthetische Analyse (DE-588)4330854-5 Nicolaou, Kyriacos (DE-588)11391041X Nicolaou, K. C. (DE-588)11391041X Nicolaou, K. (DE-588)11391041X Snyder, S. A. (DE-588)124964087 Chen, Jason (DE-588)143527339 Chen, J. S. (DE-588)143527339 Chen, J. (DE-588)143527339 Sorensen, E. J. 1966- (DE-588)172891523 Chen, Jason (DE-588)143527339 Chen, J. S. (DE-588)143527339 Chen, J. (DE-588)143527339 Sorensen, E. J. 1966- (DE-588)172891523 Nicolaou, Kyriacos (DE-588)11391041X Nicolaou, K. C. (DE-588)11391041X Nicolaou, K. (DE-588)11391041X Snyder, S. A. (DE-588)124964087 Nicolaou, Kyriacos (DE-588)11391041X Nicolaou, K. C. (DE-588)11391041X Nicolaou, K. (DE-588)11391041X Sorensen, E. J. 1966- (DE-588)172891523 Sorensen, E. J. 1966- (DE-588)172891523 Snyder, S. A. (DE-588)124964087 Chen, Jason (DE-588)143527339 Chen, J. S. (DE-588)143527339 Chen, J. (DE-588)143527339 Retrosynthetische Analyse (DE-588)4330854-5 UVB P0001 466 Bd. 2. Classics in total synthesis. More targets, strategies, methods VIEW http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=2606413&custom_att_2=simple_viewer TITEL: BD. 2. CLASSICS IN TOTAL SYNTHESIS. MORE TARGETS, STRATEGIES, METHODS AUTOR: JAHR: 2003 TABLE OF CONTENTS CHAPTER 1 INTRODUCTION: PERSPECTIVES IN TOTAL SYNTHESIS 1.1 TARGETS 2 1.2 STRATEGIES 5 1.3 METHODS 8 1.4 CLASSICS IN TOTAL SYNTHESIS II 12 CHAPTER 2 ISOCHRYSOHERMIDIN D. L. BOGER (1993) 2.1 INTRODUCTION 15 2.1.1 AZADIENE-BASED INVERSE-ELECTRON-DEMAND DIELS—ALDER REACTIONS 17 2.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 22 2.3 TOTAL SYNTHESIS 25 2.4 CONCLUSION 29 CHAPTER 3 SWINHOLIDE A I. PATERSON (1994) 3.1 INTRODUCTION 31 3.1.1 BORON-MEDIATED ASYMMETRIC ALDOL REACTIONS .... 33 3.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 46 3.3 TOTAL SYNTHESIS 50 3.4 CONCLUSION 67 3.5 NICOLAOU'S TOTAL SYNTHESIS OF SWINHOLIDE A 67 TABLE OF CONTENTS CHAPTER 4 DYNEMICIN A A. G. MYERS (1995); S. J. DANISHEFSKY (1995) 4.1 INTRODUCTION 75 4.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 78 4.2.1 MYERS'SYNTHETIC APPROACH TO DYNEMICIN A 78 4.2.2 DANISHEFSKY'S SYNTHETIC APPROACH TO DYNEMICIN A . 82 4.3 TOTAL SYNTHESIS 86 4.3.1 MYERS'TOTAL SYNTHESIS OF DYNEMICIN A 86 4.3.2 DANISHEFSKY'S TOTAL SYNTHESIS OF DYNEMICIN A . ... 96 4.4 CONCLUSION 104 4.5 SCHREIBER'S SYNTHESIS OF TRI-O-METHYL DYNEMICIN A METHYL ESTER 105 CHAPTER 5 ECTEINASCIDIN 743 E.J. COREY (1996) 5.1 INTRODUCTION 109 5.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 113 5.3 TOTAL SYNTHESIS 120 5.4 CONCLUSION 132 5.5 FUKUYAMA'S TOTAL SYNTHESIS OF ECTEINASCIDIN 743 . . 133 CHAPTER 6 RESIN IFE RA TOXIN P. A. WENDER (1997) 6.1 INTRODUCTION 137 6.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 139 6.3 TOTAL SYNTHESIS 146 6.4 CONCLUSION 157 TABLE OF CONTENTS CHAPTER 7 EPOTHILONES A AND B K. C. NICOLAOU (1997) 7.1 INTRODUCTION 161 7.1.1 OLEFIN METATHESIS: A BRIEF HISTORY 163 7.1.2 OLEFIN METATHESIS: CASE STUDIES 172 7.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 188 7.3 TOTAL SYNTHESIS 191 7.3.1 SOLUTION-PHASE SYNTHESIS OF EPOTHILONE A 191 7.3.2 SOLID-PHASE SYNTHESIS OF EPOTHILONE A 196 7.3.3 ALTERNATIVE METATHESIS APPROACHES TO THE EPOTHILONES 203 7.4 CONCLUSION 206 CHAPTER 8 MANZAMINE A J. D. WINKLER (1998); S. F. MARTIN (1999) 8.1 INTRODUCTION 211 8.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 214 8.2.1 WINKLER'S SYNTHETIC APPROACH TO MANZAMINE A ... 214 8.2.2 MARTIN'S SYNTHETIC APPROACH TO MANZAMINE A .... 218 8.3 TOTAL SYNTHESIS 222 8.3.1 WINKLER'S TOTAL SYNTHESIS OF MANZAMINE A 222 8.3.2 MARTIN'S TOTAL SYNTHESIS OF MANZAMINE A 229 8.4 CONCLUSION 236 CHAPTER 9 VANCOMYCIN K. C. NICOLAOU (1998); D.A. EVANS (1998) 9.1 INTRODUCTION 239 9.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 244 9.2.1 NICOLAOU'S SYNTHETIC APPROACH TO VANCOMYCIN AND THE VANCOMYCIN AGLYCON 244 9.2.2 EVANS' SYNTHETIC APPROACH TO THE VANCOMYCIN AGLYCON 255 TABLE OF CONTENTS 9.3 TOTAL SYNTHESIS 259 9.3.1 NICOLAOU'S TOTAL SYNTHESIS OF THE VANCOMYCIN AGLYCON 259 9.3.2 NICOLAOU'S TOTAL SYNTHESIS OF VANCOMYCIN 274 9.3.3 EVANS' TOTAL SYNTHESIS OF THE VANCOMYCIN AGLYCON . 279 9.4 CONCLUSION 293 9.5 BOGER'S TOTAL SYNTHESIS OF THE VANCOMYCIN AGLYCON . 293 CHAPTER 10 EVERNINOMICIN 13,384-1 K. C. NICOLAOU (1999) 10.1 INTRODUCTION 301 10.1.1 GLYCOSIDATION METHODS IN CARBOHYDRATE SYNTHESIS . . 302 10.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 314 10.3 TOTAL SYNTHESIS 322 10.3.1 SYNTHESIS OF THE A'B(A)C FRAGMENT 322 10.3.2 SYNTHESIS OF THE FGHA2 FRAGMENT 331 10.3.3 SYNTHESIS OF THE DE FRAGMENT 340 10.3.4 FINAL STAGES AND COMPLETION OF THE TOTAL SYNTHESIS OF EVERNINOMICIN 13,384-1 344 10.4 CONCLUSION 348 CHAPTER 11 BISORBICILLINOIDS K. C. NICOLAOU (1999) 11.1 INTRODUCTION 351 11.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 356 11.3 TOTAL SYNTHESIS 358 11.4 CONCLUSION 363 CHAPTER 12 ASPIDOPHYTINE E. J. COREY (1999) 12.1 INTRODUCTION 365 12.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 366 12.3 TOTAL SYNTHESIS 370 12.4 CONCLUSION 378 TABLE OF CONTENTS CHAPTER 13 CP-MOLECULES K. C. NICOLAOU (1999) 13.1 INTRODUCTION 381 13.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 384 13.3 TOTAL SYNTHESIS 388 13.4 CONCLUSION 410 13.5 FUKUYAMA'S TOTAL SYNTHESIS OF THE CP-MOLECULES . . 411 13.6 SHAIR'S TOTAL SYNTHESIS OF THE CP-MOLECULES 413 13.7 DANISHEFSKY'S TOTAL SYNTHESIS OF THE CP-MOLECULES .416 CHAPTER 14 COLOMBIASIN A K. C. NICOLAOU (2001) HA INTRODUCTION 423 14.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 425 14.3 TOTAL SYNTHESIS 430 14.4 CONCLUSION 440 CHAPTER 15 QUININE G. STORK (2001) 15.1 INTRODUCTION 443 15.1.1 INITIAL SYNTHETIC FORAYS 444 15.1.2 THE WOODWARD/DOERING FORMAL TOTAL SYNTHESIS . . . 448 15.1.3 THE HOFFMANN-LA ROCHE TOTAL SYNTHESIS 452 15.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 456 15.3 TOTAL SYNTHESIS 458 15.4 CONCLUSION 462 CHAPTER 16 LONGITHORONE A M. D. SHAIR (2002) 16.1 INTRODUCTION 465 16.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 467 16.3 TOTAL SYNTHESIS 474 16.4 CONCLUSION 481 TABLE OF CONTENTS CHAPTER 17 (-)-FR182877 E. J. SORENSEN (2002) 17.1 INTRODUCTION 483 17.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 489 17.3 TOTAL SYNTHESIS 493 17.4 CONCLUSION 499 17.5 EVANS'TOTAL SYNTHESIS OF (-)-FR182877 500 CHAPTER 18 VINBLASTINE T. FUKUYAMA (2002) 18.1 INTRODUCTION 505 18.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 509 18.3 TOTAL SYNTHESIS 518 18.4 CONCLUSION 530 CHAPTER 19 QUADRIGEMINE C AND PSYCHOLEINE L. E. OVERMAN (2002) 19.1 INTRODUCTION 533 19.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 535 19.3 TOTAL SYNTHESIS 539 19.4 CONCLUSION 547 CHAPTER 20 DIAZONAMIDE A K. C. NICOLAOU (2002; 2003) 20.1 INTRODUCTION 551 20.2 RETROSYNTHETIC ANALYSIS 556 20.3 TOTAL SYNTHESIS 565 20.3.1 THE FIRST TOTAL SYNTHESIS OF DIAZONAMIDE A 565 20.3.2 THE SECOND TOTAL SYNTHESIS OF DIAZONAMIDE A .... 572 20.4 CONCLUSION 585 TABLE OF CONTENTS CHAPTER 21 PLICAMINE S. V. LEY (2002) 21.1 INTRODUCTION 589 21.1.1 SOLID-SUPPORTED REAGENTS 590 21.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 595 21.3 TOTAL SYNTHESIS 597 21.4 CONCLUSION 602 CHAPTER 22 OKARAMINE N E. J. COREY (2003) 22.1 INTRODUCTION 605 22.2 RETROSYNTHETIC ANALYSIS AND STRATEGY 606 22.3 TOTAL SYNTHESIS 612 22.4 CONCLUSION 618 AUTHOR INDEX 621 SUBJECT INDEX 623 UP PAD01 000870753 2;^.^More targets, strategies, methods.^2003 Classics in total synthesis.^1996 BOOK P0001 41 UVB3677-2 03/8879 20 20031008 810587-10 BOOK P0001 41 UVB3677-2+1 08/10529 43 20081008 810587-20 BOOK P0001 41 UVB3677-2+2 11/14774 20 20111219 810587-30 BOOK P0001 20 00000000 810587-40