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Halophila ovalis and its closely-related species belonging to the Hydrocharitaceae are well-known as a complex taxonomic challenge mainly due to their high morphological plasticity. The relationship of genetic differentiation and geographic barriers of H. ovalis radiation was not much studied in this region. Are there misidentifications between H. ovalis and its closely related species? Does any taxonomic uncertainty among different populations of H. ovalis persist? Is there any genetic differentiation among populations in the Western Pacific and the Eastern Indian Ocean, which are separated by the Thai-Malay peninsula? Genetic markers can be used to characterize and identify individuals or species and will be used to answer these questions. Results: Phylogenetic analyses of the nuclear ribosomal internal transcribed spacer region based on materials collected from 17 populations in the Western Pacific and the Eastern Indian Ocean showed that some specimens identified as H. ovalis belonged to the H. major clade, also supported by morphological data. Evolutionary divergence between the two clades is between 0.033 and 0.038, much higher than the evolutionary divergence among H. ovalis populations. Eight haplotypes were found; none of the haplotypes from the Western Pacific is found in India and vice versa. Analysis of genetic diversity based on microsatellite analysis revealed that the genetic diversity in the Western Pacific is higher than in the Eastern Indian Ocean. The unrooted neighbor-joining tree among 14 populations from the Western Pacific and the Eastern Indian Ocean showed six groups. The Mantel test results revealed a significant correlation between genetic and geographic distances among populations. Results from band-based and allele frequency-based approaches from Amplified Fragment Length Polymorphism showed that all samples collected from both sides of the Thai-Malay peninsula were clustered into two clades: Gulf of Thailand and Andaman Sea. Conclusions: Our study documented the new records of H. major for Malaysia and Myanmar. The study also revealed that the Thai-Malay peninsula is a geographic barrier between H. ovalis populations in the Western Pacific and the Eastern Indian Ocean.", "descriptionType": "Abstract" }, { "description": "publishedVersion", "descriptionType": "Other" }], "geoLocations": [], "fundingReferences": [], "url": "http://www.repo.uni-hannover.de:8070/handle/123456789/376", "contentUrl": null, "metadataVersion": 0, "schemaVersion": null, "source": null, "isActive": true, "state": "findable", "reason": null, "created": "2015-08-01T03:07:13.000Z", "registered": "2015-08-01T03:27:03.000Z", "published": "2014", "updated": "2019-05-29T03:31:49.000Z" }, "relationships": { "client": { "data": { "id": "tib.luhrepo", "type": "clients" } } } }, { "id": "10.15488/137", "type": "dois", "attributes": { "doi": "10.15488/137", "identifiers": [{ "identifier": "https://handle.test.datacite.org/10.15488/137", "identifierType": "DOI" }, { "identifier": "Hirschmann, Felix; Krause, Florian; Papenbrock, Jutta: The multi-protein family of sulfotransferases in plants: composition, occurrence, substrate specificity, and functions. In: Froniers in Plant Science 5 (2014). DOI: http://dx.doi.org/10.3389/fpls.2014.00556", "identifierType": "citation" }, { "identifier": "http://www.repo.uni-hannover.de:8070/handle/123456789/377", "identifierType": "uri" }], "creators": [{ "name": "Hirschmann, Felix", "nameType": "Personal", "givenName": "Felix", "familyName": "Hirschmann" }, { "name": "Krause, Florian", "nameType": "Personal", "givenName": "Florian", "familyName": "Krause" }, { "name": "Papenbrock, Jutta", "nameType": "Personal", "givenName": "Jutta", "familyName": "Papenbrock" }], "titles": [{ "title": "The multi-protein family of sulfotransferases in plants: composition, occurrence, substrate specificity, and functions" }], "publisher": "Leibniz Universität Hannover", "container": null, "publicationYear": 2014, "subjects": [{ "subject": "Arabidopsis thaliana" }, { "subject": "glucosinolate" }, { "subject": "histidine residue" }, { "subject": "phosphoadenosine 5 ‘-phosphosulfate" }, { "subject": "Sulfotransferase" }, { "subject": "580", "subjectScheme": "ddc" }], "contributors": [{ "name": "Leibniz Universität Hannover" }, { "name": "Leibniz Universität Hannover" }], "dates": [{ "date": "2015-07-31", "dateType": "Issued" }, { "date": "2015-07-31", "dateType": "Available" }, { "date": "2014", "dateType": "Issued" }], "language": null, "types": { "ris": "GEN", "bibtex": "misc", "citeproc": "article", "schemaOrg": "Collection", "resourceType": "article", "resourceTypeGeneral": "Collection" }, "relatedIdentifiers": [], "sizes": [], "formats": [], "version": null, "rightsList": [], "descriptions": [{ "description": "All members of the sulfotransferase (SOT, EC 2.8.2.-) protein family transfer a sulfuryl group from the donor 3’-phosphoadenosine 5’-phosphosulfate (PAPS) to an appropriate hydroxyl group of several classes of substrates. The primary structure of these enzymes is characterized by a histidine residue in the active site, defined PAPS binding sites and a longer SOT domain. Proteins with this SOT domain occur in all organisms from all three domains, usually as a multi-protein family. Arabidopsis thaliana SOTs, the best characterized SOT multi-protein family, contains 21 members. The substrates for several plant enzymes have already been identified, such as glucosinolates, brassinosteroids, jasmonates, flavonoids, and salicylic acid. Much information has been gathered on desulfoglucosinolate (dsGl) SOTs in A. thaliana. The three cytosolic dsGI SOTs show slightly different expression patterns. The recombinant proteins reveal differences in their affinity to indolic and aliphatic dsGls. Also the respective recombinant dsGl SOTs from different A. thaliana ecotypes differ in their kinetic properties. However, determinants of substrate specificity and the exact reaction mechanism still need to be clarified. Probably, the three-dimensional structures of more plant proteins need to be solved to analyze the mode of action and the responsible amino acids for substrate binding. In addition to A. thaliana, more plant species from several families need to be investigated to fully elucidate the diversity of sulfated molecules and the way of biosynthesis catalyzed by SOT enzymes.", "descriptionType": "Abstract" }, { "description": "publishedVersion", "descriptionType": "Other" }], "geoLocations": [], "fundingReferences": [], "url": "http://www.repo.uni-hannover.de:8070/handle/123456789/377", "contentUrl": null, "metadataVersion": 0, "schemaVersion": null, "source": null, "isActive": true, "state": "findable", "reason": null, "created": "2015-08-01T03:07:14.000Z", "registered": "2015-08-01T03:27:07.000Z", "published": "2014", "updated": "2019-05-25T17:31:35.000Z" }, "relationships": { "client": { "data": { "id": "tib.luhrepo", "type": "clients" } } } }, { "id": "10.15488/138", "type": "dois", "attributes": { "doi": "10.15488/138", "identifiers": [{ "identifier": "https://handle.test.datacite.org/10.15488/138", "identifierType": "DOI" }, { "identifier": "Weese, Annekathrin; Pallmann, Philip; Papenbrock, Jutta; Riemenschneider, Anja: Brassica napus L. cultivars show a broad variability in their morphology, physiology and metabolite levels in response to sulfur limitations and to pathogen attack. In: Frontiers in Plant Science 6 (2015), Nr. 9. DOI: http://dx.doi.org/10.3389/fpls.2015.00009", "identifierType": "citation" }, { "identifier": "http://www.repo.uni-hannover.de:8070/handle/123456789/378", "identifierType": "uri" }], "creators": [{ "name": "Weese, Annekathrin", "nameType": "Personal", "givenName": "Annekathrin", "familyName": "Weese" }, { "name": "Pallmann, Philip", "nameType": "Personal", "givenName": "Philip", "familyName": "Pallmann" }, { "name": "Papenbrock, Jutta", "nameType": "Personal", "givenName": "Jutta", "familyName": "Papenbrock" }, { "name": "Riemenschneider, Anja", "nameType": "Personal", "givenName": "Anja", "familyName": "Riemenschneider" }], "titles": [{ "title": "Brassica napus L. cultivars show a broad variability in their morphology, physiology and metabolite levels in response to sulfur limitations and to pathogen attack" }], "publisher": "Leibniz Universität Hannover", "container": null, "publicationYear": 2015, "subjects": [{ "subject": "canola" }, { "subject": "diurnal rhythm" }, { "subject": "elemental sulfur" }, { "subject": "metabolites" }, { "subject": "Verticillium longisporum" }, { "subject": "Dewey Decimal Classification::500 | Naturwissenschaften::580 | Pflanzen (Botanik)", "subjectScheme": "ddc" }], "contributors": [{ "name": "Leibniz Universität Hannover" }, { "name": "Leibniz Universität Hannover" }], "dates": [{ "date": "2015-07-31", "dateType": "Issued" }, { "date": "2015-07-31", "dateType": "Available" }, { "date": "2015", "dateType": "Issued" }], "language": null, "types": { "ris": "GEN", "bibtex": "misc", "citeproc": "article", "schemaOrg": "Collection", "resourceType": "article", "resourceTypeGeneral": "Collection" }, "relatedIdentifiers": [], "sizes": [], "formats": [], "version": null, "rightsList": [], "descriptions": [{ "description": "Under adequate sulfur supply, plants accumulate sulfate in the vacuoles and use sulfur-containing metabolites as storage compounds. Under sulfur-limiting conditions, these pools of stored sulfur-compounds are depleted in order to balance the nitrogen to sulfur ratio for protein synthesis. Stress conditions like sulfur limitation and/or pathogen attack induce changes in the sulfate pool and the levels of sulfur-containing metabolites, which often depend on the ecotypes or cultivars. We are interested in investigating the influence of the genetic background of canola (Brassica napus) cultivars in sulfur-limiting conditions on the resistance against Verticillium longisporum. Therefore, four commercially available Brassica. napus cultivars were analyzed. These high-performing cultivars differ in some characteristics described in their cultivar pass, such as several agronomic traits, differences in the size of the root system, and resistance to certain pathogens, such as Phoma and Verticillium. The objectives of the study were to examine and explore the patterns of morphological, physiological and metabolic diversity in these Brassica. napus cultivars at different sulfur concentrations and in the context of plant defense. Results indicate that the root systems are influenced differently by sulfur deficiency in the cultivars. Total root dry mass and length of root hairs differ not only among the cultivars but also vary in their reaction to sulfur limitation and pathogen attack. As a sensitive indicator of stress, several parameters of photosynthetic activity determined by PAM imaging showed a broad variability among the treatments. These results were supported by thermographic analysis. Levels of sulfur-containing metabolites also showed large variations. The data were interrelated to predict the specific behavior during sulfur limitation and/or pathogen attack. Advice for farming are discussed.", "descriptionType": "Abstract" }, { "description": "publishedVersion", "descriptionType": "Other" }], "geoLocations": [], "fundingReferences": [], "url": "http://www.repo.uni-hannover.de:8070/handle/123456789/378", "contentUrl": null, "metadataVersion": 0, "schemaVersion": null, "source": null, "isActive": true, "state": "findable", "reason": null, "created": "2015-08-01T03:07:16.000Z", "registered": "2015-08-01T03:27:09.000Z", "published": "2015", "updated": "2019-05-25T15:00:48.000Z" }, "relationships": { "client": { "data": { "id": "tib.luhrepo", "type": "clients" } } } }, { "id": "10.15488/139", "type": "dois", "attributes": { "doi": "10.15488/139", "identifiers": [{ "identifier": "https://handle.test.datacite.org/10.15488/139", "identifierType": "DOI" }, { "identifier": "Boestfleisch, Christian; Wagenseil, Niko B.; Buhmann, Anne K.; Seal, Charlotte E.; Wade, Ellie Merrett; Muscolo, Adele; Papenbrock, Jutta: Manipulating the antioxidant capacity of halophytes to increase their cultural and economic value through saline cultivation. In: AOB PLANTS 6 (2014). DOI: http://dx.doi.org/10.1093/aobpla/plu046", "identifierType": "citation" }, { "identifier": "http://www.repo.uni-hannover.de:8070/handle/123456789/379", "identifierType": "uri" }], "creators": [{ "name": "Boestfleisch, Christian", "nameType": "Personal", "givenName": "Christian", "familyName": "Boestfleisch" }, { "name": "Wagenseil, Niko B.", "nameType": "Personal", "givenName": "Niko B.", "familyName": "Wagenseil" }, { "name": "Buhmann, Anne K.", "nameType": "Personal", "givenName": "Anne K.", "familyName": "Buhmann" }, { "name": "Seal, Charlotte E.", "nameType": "Personal", "givenName": "Charlotte E.", "familyName": "Seal" }, { "name": "Wade, Ellie Merrett", "nameType": "Personal", "givenName": "Ellie Merrett", "familyName": "Wade" }, { "name": "Muscolo, Adele", "nameType": "Personal", "givenName": "Adele", "familyName": "Muscolo" }, { "name": "Papenbrock, Jutta", "nameType": "Personal", "givenName": "Jutta", "familyName": "Papenbrock" }], "titles": [{ "title": "Manipulating the antioxidant capacity of halophytes to increase their cultural and economic value through saline cultivation" }], "publisher": "Leibniz Universität Hannover", "container": {}, "publicationYear": 2014, "subjects": [{ "subject": "Halophytes" }, { "subject": "nutraceuticals" }, { "subject": "secondary metabolites" }, { "subject": "stress tolerance" }, { "subject": "yield" }, { "subject": "580", "subjectScheme": "ddc" }], "contributors": [{ "name": "Leibniz Universität Hannover" }, { "name": "Leibniz Universität Hannover" }], "dates": [{ "date": "2015-07-31", "dateType": "Issued" }, { "date": "2015-07-31", "dateType": "Available" }, { "date": "2014", "dateType": "Issued" }], "language": null, "types": { "ris": "GEN", "bibtex": "misc", "citeproc": "article", "schemaOrg": "Collection", "resourceType": "article", "resourceTypeGeneral": "Collection" }, "relatedIdentifiers": [], "sizes": [], "formats": [], "version": null, "rightsList": [], "descriptions": [{ "description": "Halophytes, salt-tolerant plants, are a source of valuable secondary metabolites with potential economic value. The steady-state pools of many stress-related metabolites are already enhanced in halophytes when compared with glycophytes, but growth under conditions away from the optimum can induce stress and consequently result in changes to secondary metabolites such as antioxidants. However, direct evidence for increasing the concentration of valuable secondary metabolites as a consequence of altering the salinity of the growing environment still remains equivocal. To address this, we analysed a range of metabolites with antioxidant capacity (including total phenols, flavonoids, ascorbate, reduced/oxidized glutathione and reactive oxygen species scavenging enzymes) in seedlings and plants from different families (Amaranthaceae, Brassicaceae, Plantaginaceae and Rhizophoraceae) and habitats grown under different salt concentrations. We show that it is possible to manipulate the antioxidant capacity of plants and seedlings by altering the saline growing environment, the length of time under saline cultivation and the developmental stage. Among the species studied, the halophytes Tripolium pannonicum, Plantago coronopus, Lepidium latifolium and Salicornia europaea demonstrated the most potential as functional foods or nutraceuticals.", "descriptionType": "Abstract" }, { "description": "publishedVersion", "descriptionType": "Other" }], "geoLocations": [], "fundingReferences": [], "url": "http://www.repo.uni-hannover.de:8070/handle/123456789/379", "contentUrl": null, "metadataVersion": 0, "schemaVersion": null, "source": null, "isActive": true, "state": "findable", "reason": null, "created": "2015-08-01T03:07:17.000Z", "registered": "2015-08-01T03:27:19.000Z", "published": "2014", "updated": "2019-05-19T15:07:48.000Z" }, "relationships": { "client": { "data": { "id": "tib.luhrepo", "type": "clients" } } } }, { "id": "10.15488/140", "type": "dois", "attributes": { "doi": "10.15488/140", "identifiers": [{ "identifier": "https://handle.test.datacite.org/10.15488/140", "identifierType": "DOI" }, { "identifier": "Singh, Devesh; Buhmann, Anne K.; Flowers, Tim J.; Seal, Charlotte E.; Papenbrock, Jutta: Salicornia as a crop plant in temperate regions: selection of genetically characterized ecotypes and optimization of their cultivation conditions. In: AOB PLANTS 6 (2014). DOI: http://dx.doi.org/10.1093/aobpla/plu071", "identifierType": "citation" }, { "identifier": "http://www.repo.uni-hannover.de:8070/handle/123456789/380", "identifierType": "uri" }], "creators": [{ "name": "Singh, Devesh", "nameType": "Personal", "givenName": "Devesh", "familyName": "Singh" }, { "name": "Buhmann, Anne K.", "nameType": "Personal", "givenName": "Anne K.", "familyName": "Buhmann" }, { "name": "Flowers, Tim J.", "nameType": "Personal", "givenName": "Tim J.", "familyName": "Flowers" }, { "name": "Seal, Charlotte E.", "nameType": "Personal", "givenName": "Charlotte E.", "familyName": "Seal" }, { "name": "Papenbrock, Jutta", "nameType": "Personal", "givenName": "Jutta", "familyName": "Papenbrock" }], "titles": [{ "title": "Salicornia as a crop plant in temperate regions: selection of genetically characterized ecotypes and optimization of their cultivation conditions" }], "publisher": "Leibniz Universität Hannover", "container": {}, "publicationYear": 2014, "subjects": [{ "subject": "Biomass" }, { "subject": "ETS" }, { "subject": "germination" }, { "subject": "Salicornia species" }, { "subject": "salinity" }, { "subject": "Dewey Decimal Classification::500 | Naturwissenschaften::580 | Pflanzen (Botanik)", "subjectScheme": "ddc" }], "contributors": [{ "name": "Leibniz Universität Hannover" }, { "name": "Leibniz Universität Hannover" }], "dates": [{ "date": "2015-07-31", "dateType": "Issued" }, { "date": "2015-07-31", "dateType": "Available" }, { "date": "2014", "dateType": "Issued" }], "language": null, "types": { "ris": "GEN", "bibtex": "misc", "citeproc": "article", "schemaOrg": "Collection", "resourceType": "article", "resourceTypeGeneral": "Collection" }, "relatedIdentifiers": [], "sizes": [], "formats": [], "version": null, "rightsList": [], "descriptions": [{ "description": "Rising sea levels and salinization of groundwater due to global climate change result in fast-dwindling sources of freshwater. Therefore, it is important to find alternatives to grow food crops and vegetables. Halophytes are naturally evolved salt-tolerant plants that are adapted to grow in environments that inhibit the growth of most glycophytic crop plants substantially. Members of the Salicornioideae are promising candidates for saline agriculture due to their high tolerance to salinity. Our aim was to develop genetically characterized lines of Salicornia and Sarcocornia for further breeding and to determine optimal cultivation conditions. To obtain a large and diverse genetic pool, seeds were collected from different countries and ecological conditions. The external transcribed spacer (ETS) sequence of 62 Salicornia and Sarcocornia accessions was analysed: ETS sequence data showed a clear distinction between the two genera and between different Salicornia taxa. However, in some cases the ETS was not sufficiently variable to resolve morphologically distinct species. For the determination of optimal cultivation conditions, experiments on germination, seedling establishment and growth to a harvestable size were performed using different accessions of Salicornia spp. Experiments revealed that the percentage germination was greatest at lower salinities and with temperatures of 20/10 degrees C (day/night). Salicornia spp. produced more harvestable biomass in hydroponic culture than in sand culture, but the nutrient concentration requires optimization as hydroponically grown plants showed symptoms of stress. Salicornia ramosissima produced more harvestable biomass than Salicornia dolichostachya in artificial sea water containing 257 mM NaCl. Based on preliminary tests on ease of cultivation, gain in biomass, morphology and taste, S. dolichostachya was investigated in more detail, and the optimal salinity for seedling establishment was found to be 100 mM. Harvesting of S. dolichostachya twice in a growing season was successful, but the interval between the harvests needs to be optimized to maximize biomass production.", "descriptionType": "Abstract" }, { "description": "publishedVersion", "descriptionType": "Other" }], "geoLocations": [], "fundingReferences": [], "url": "http://www.repo.uni-hannover.de:8070/handle/123456789/380", "contentUrl": null, "metadataVersion": 0, "schemaVersion": null, "source": null, "isActive": true, "state": "findable", "reason": null, "created": "2015-08-01T03:07:19.000Z", "registered": "2015-08-01T03:27:21.000Z", "published": "2014", "updated": "2019-05-05T22:03:07.000Z" }, "relationships": { "client": { "data": { "id": "tib.luhrepo", "type": "clients" } } } }, { "id": "10.15488/141", "type": "dois", "attributes": { "doi": "10.15488/141", "identifiers": [{ "identifier": "https://handle.test.datacite.org/10.15488/141", "identifierType": "DOI" }, { "identifier": "Lucas, Christina; Thangaradjou, Thirunavakkarasu; Papenbrock, Jutta: Development of a DNA Barcoding System for Seagrasses: Successful but Not Simple. In: PLoS ONE 7 (2012), Nr. 1. DOI: http://dx.doi.org/10.1371/journal.pone.0029987", "identifierType": "citation" }, { "identifier": "http://www.repo.uni-hannover.de:8070/handle/123456789/381", "identifierType": "uri" }], "creators": [{ "name": "Lucas, Christina", "nameType": "Personal", "givenName": "Christina", "familyName": "Lucas" }, { "name": "Thangaradjou, Thirunavakkarasu", "nameType": "Personal", "givenName": "Thirunavakkarasu", "familyName": "Thangaradjou" }, { "name": "Papenbrock, Jutta", "nameType": "Personal", "givenName": "Jutta", "familyName": "Papenbrock" }], "titles": [{ "title": "Development of a DNA Barcoding System for Seagrasses: Successful but Not Simple" }], "publisher": "Leibniz Universität Hannover", "container": {}, "publicationYear": 2012, "subjects": [{ "subject": "Dewey Decimal Classification::500 | Naturwissenschaften::580 | Pflanzen (Botanik)", "subjectScheme": "ddc" }], "contributors": [{ "name": "Leibniz Universität Hannover" }, { "name": "Leibniz Universität Hannover" }], "dates": [{ "date": "2015-07-31", "dateType": "Issued" }, { "date": "2015-07-31", "dateType": "Available" }, { "date": "2012", "dateType": "Issued" }], "language": null, "types": { "ris": "GEN", "bibtex": "misc", "citeproc": "article", "schemaOrg": "Collection", "resourceType": "article", "resourceTypeGeneral": "Collection" }, "relatedIdentifiers": [], "sizes": [], "formats": [], "version": null, "rightsList": [], "descriptions": [{ "description": "Seagrasses, a unique group of submerged flowering plants, profoundly influence the physical, chemical and biological environments of coastal waters through their high primary productivity and nutrient recycling ability. They provide habitat for aquatic life, alter water flow, stabilize the ground and mitigate the impact of nutrient pollution. at the coast region. Although on a global scale seagrasses represent less than 0.1% of the angiosperm taxa, the taxonomical ambiguity in delineating seagrass species is high. Thus, the taxonomy of several genera is unsolved. While seagrasses are capable of performing both, sexual and asexual reproduction, vegetative reproduction is common and sexual progenies are always short lived and epimeral in nature. This makes species differentiation often difficult, especially for non-taxonomists since the flower as a distinct morphological trait is missing. Our goal is to develop a DNA barcoding system assisting also non-taxonomists to identify regional seagrass species. The results will be corroborated by publicly available sequence data. The main focus is on the 14 described seagrass species of India, supplemented with seagrasses from temperate regions. According to the recommendations of the Consortium for the Barcoding of Life (CBOL) rbcL and matK were used in this study. After optimization of the DNA extraction method from preserved seagrass material, the respective sequences were amplified from all species analyzed. Tree-and character-based approaches demonstrate that the rbcL sequence fragment is capable of resolving up to family and genus level. Only matK sequences were reliable in resolving species and partially the ecotype level. Additionally, a plastidic gene spacer was included in the analysis to confirm the identification level. Although the analysis of these three loci solved several nodes, a few complexes remained unsolved, even when constructing a combined tree for all three loci. Our approaches contribute to the understanding of the morphological plasticity of seagrasses versus genetic differentiation.", "descriptionType": "Abstract" }, { "description": "publishedVersion", "descriptionType": "Other" }], "geoLocations": [], "fundingReferences": [], "url": "http://www.repo.uni-hannover.de:8070/handle/123456789/381", "contentUrl": null, "metadataVersion": 0, "schemaVersion": null, "source": null, "isActive": true, "state": "findable", "reason": null, "created": "2015-08-01T03:07:20.000Z", "registered": "2015-08-01T03:27:23.000Z", "published": "2012", "updated": "2019-05-24T20:31:00.000Z" }, "relationships": { "client": { "data": { "id": "tib.luhrepo", "type": "clients" } } } }, { "id": "10.15488/142", "type": "dois", "attributes": { "doi": "10.15488/142", "identifiers": [{ "identifier": "https://handle.test.datacite.org/10.15488/142", "identifierType": "DOI" }, { "identifier": "Remelli, William; Guerrieri, Nicoletta; Klodmann, Jennifer; Papenbrock, Jutta; Pagani, Silvia; Forlani, Fabio: Involvement of the Azotobacter vinelandii Rhodanese-Like Protein RhdA in the Glutathione Regeneration Pathway. In: PLoS ONE 7 (2012), Nr. 9. DOI: http://dx.doi.org/ 10.1371/journal.pone.0045193", "identifierType": "citation" }, { "identifier": "http://www.repo.uni-hannover.de:8070/handle/123456789/382", "identifierType": "uri" }], "creators": [{ "name": "Remelli, William", "nameType": "Personal", "givenName": "William", "familyName": "Remelli" }, { "name": "Guerrieri, Nicoletta", "nameType": "Personal", "givenName": "Nicoletta", "familyName": "Guerrieri" }, { "name": "Klodmann, Jennifer", "nameType": "Personal", "givenName": "Jennifer", "familyName": "Klodmann" }, { "name": "Papenbrock, Jutta", "nameType": "Personal", "givenName": "Jutta", "familyName": "Papenbrock" }, { "name": "Pagani, Silvia", "nameType": "Personal", "givenName": "Silvia", "familyName": "Pagani" }, { "name": "Forlani, Fabio", "nameType": "Personal", "givenName": "Fabio", "familyName": "Forlani" }], "titles": [{ "title": "Involvement of the Azotobacter vinelandii Rhodanese-Like Protein RhdA in the Glutathione Regeneration Pathway" }], "publisher": "Leibniz Universität Hannover", "container": {}, "publicationYear": 2012, "subjects": [{ "subject": "RhdA" }, { "subject": "Rhodanese-like proteins" }, { "subject": "Azotobacter vinelandii" }, { "subject": "Glutathione" }, { "subject": "Oxidative stress" }, { "subject": "Thiyl radicals" }, { "subject": "Settore BIO/10 - Biochimica" }, { "subject": "580", "subjectScheme": "ddc" }], "contributors": [{ "name": "Leibniz Universität Hannover" }, { "name": "Leibniz Universität Hannover" }], "dates": [{ "date": "2015-07-31", "dateType": "Issued" }, { "date": "2015-07-31", "dateType": "Available" }, { "date": "2012", "dateType": "Issued" }], "language": null, "types": { "ris": "GEN", "bibtex": "misc", "citeproc": "article", "schemaOrg": "Collection", "resourceType": "article", "resourceTypeGeneral": "Collection" }, "relatedIdentifiers": [], "sizes": [], "formats": [], "version": null, "rightsList": [], "descriptions": [{ "description": "The phenotypic features of the Azotobacter vinelandii RhdA mutant MV474 (in which the rhdA gene was deleted) indicated that defects in antioxidant systems in this organism were related to the expression of the tandem-domain rhodanese RhdA. In this work, further insights on the effects of the oxidative imbalance generated by the absence of RhdA (e.g. increased levels of lipid hydroperoxides) are provided. Starting from the evidence that glutathione was depleted in MV474, and using both in silico and in vitro approaches, here we studied the interaction of wild-type RhdA and Cys(230) Ala site-directed RhdA mutant with glutathione species. We found that RhdA was able to bind in vitro reduced glutathione (GSH) and that RhdA-Cys(230) residue was mandatory for the complex formation. RhdA catalyzed glutathione-disulfide formation in the presence of a system generating the glutathione thiyl radical (GS(.), an oxidized form of GSH), thereby facilitating GSH regeneration. This reaction was negligible when the Cys230 Ala RhdA mutant was used. The efficiency of RhdA as catalyst in GS(.)-scavenging activity is discussed on the basis of the measured parameters of both interaction with glutathione species and kinetic studies.", "descriptionType": "Abstract" }, { "description": "publishedVersion", "descriptionType": "Other" }], "geoLocations": [], "fundingReferences": [], "url": "http://www.repo.uni-hannover.de:8070/handle/123456789/382", "contentUrl": null, "metadataVersion": 0, "schemaVersion": null, "source": null, "isActive": true, "state": "findable", "reason": null, "created": "2015-08-01T03:07:22.000Z", "registered": "2015-08-01T03:27:24.000Z", "published": "2012", "updated": "2019-05-23T15:31:21.000Z" }, "relationships": { "client": { "data": { "id": "tib.luhrepo", "type": "clients" } } } }, { "id": "10.15488/143", "type": "dois", "attributes": { "doi": "10.15488/143", "identifiers": [{ "identifier": null, "identifierType": "DOI" }], "creators": [], "titles": [], "publisher": null, "container": {}, "publicationYear": 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Since these two series are cointegrated during the sample period (January 1961–June 2013), a short-run dynamic model is thus estimated for each country in which all coefficients and the error-variance terms can freely switch over time between two values prevailing in Regimes 0 and 1. Previous studies indicate that the price of crude oil does not currently affect the aggregate CPI as much as it did in the 1970s. This finding is not disputed in this paper. However, the sequentially-determined break date as well as the time-varying regime-switching probabilities point to two new findings. First, the marginal effects of changes in oil price on consumer energy prices (not the aggregate CPI) have consistently increased and become more instantaneous for both countries after the Western U.S. Energy Crisis of 2000. Second, the speed of adjustment (proxied by different error-correction coefficients) has also risen, particularly for the U.S. Therefore, oil prices exert far more positive and immediate impacts on energy costs in the post- rather than pre-1999 periods.", "descriptionType": "Abstract" }], "geoLocations": [], "fundingReferences": [], "url": null, "contentUrl": null, "metadataVersion": 0, "schemaVersion": "http://datacite.org/schema/kernel-3", "source": null, "isActive": true, "state": "findable", "reason": null, "created": "2016-08-23T10:53:17.000Z", "registered": "2016-08-23T10:53:18.000Z", "published": "2016", "updated": "2018-01-19T14:11:42.000Z" }, "relationships": { "client": { "data": { "id": "bl.mendeley", "type": "clients" } } } }, { "id": "10.17863/cam.1677", "type": "dois", "attributes": { "doi": "10.17863/cam.1677", "identifiers": [{ "identifier": "https://handle.test.datacite.org/10.17863/cam.1677", "identifierType": "DOI" }, { "identifier": 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"rightsList": [], "descriptions": [{ "description": "This article reports on a pilot of a novel ontology-based e-assessment system in accounting that draws on the potential of emerging semantic technologies to produce an online assessment environment capable of marking students' free-text answers to questions of a conceptual nature. It does this by matching their response with a \"concept map\" or \"ontology\" of domain knowledge expressed by subject specialists. The system used, OeLe, allows not only for marking, but also for feedback to individual students and teachers about student strengths and weaknesses, as well as to whole cohorts, thus providing both a formative and a summative assessment function. This article reports on the results of a \"proof of concept\" trial of OeLe, in which the system was implemented and evaluated outside its original development environment (an online course in education being used instead in an undergraduate course in financial accounting. It describes the potential affordances and demands of implementing ontology-based assessment in accounting, together with suggestions of what needs to be done if such approaches are to be more widely implemented. © 2013 Elsevier Ltd.", "descriptionType": "Abstract" }], "geoLocations": [], "fundingReferences": [], "url": null, "contentUrl": null, "metadataVersion": 26, "schemaVersion": "http://datacite.org/schema/kernel-4", "source": "mds", "isActive": true, "state": "findable", "reason": null, "created": "2016-10-05T06:49:40.000Z", "registered": null, "published": "2016", "updated": "2019-01-26T08:06:03.000Z" }, "relationships": { "client": { "data": { "id": "bl.cam", "type": "clients" } } } }, { "id": "10.17863/cam.4318", "type": "dois", "attributes": { "doi": "10.17863/cam.4318", "identifiers": [{ "identifier": "https://handle.test.datacite.org/10.17863/cam.4318", "identifierType": "DOI" }, { "identifier": "1553-7390", "identifierType": "ISSN" }, { "identifier": 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"givenName": "Andrew D", "familyName": "Morris" }, { "name": "Palmer, Colin NA", "nameType": "Personal", "givenName": "Colin NA", "familyName": "Palmer" }, { "name": "Collins, Francis S", "nameType": "Personal", "givenName": "Francis S", "familyName": "Collins" }, { "name": "Mohlke, Karen L", "nameType": "Personal", "givenName": "Karen L", "familyName": "Mohlke" }, { "name": "Bergman, Richard N", "nameType": "Personal", "givenName": "Richard N", "familyName": "Bergman" }, { "name": "Ingelsson, Erik", "nameType": "Personal", "givenName": "Erik", "familyName": "Ingelsson" }, { "name": "Lind, Lars", "nameType": "Personal", "givenName": "Lars", "familyName": "Lind" }, { "name": "Tuomilehto, Jaakko", "nameType": "Personal", "givenName": "Jaakko", "familyName": "Tuomilehto" }, { "name": "Hansen, Torben", "nameType": "Personal", "givenName": "Torben", "familyName": "Hansen" }, { "name": "Watanabe, Richard M", "nameType": "Personal", "givenName": "Richard M", "familyName": "Watanabe" }, { "name": "Prokopenko, Inga", "nameType": "Personal", "givenName": "Inga", "familyName": "Prokopenko" }, { "name": "Dupuis, Josee", "nameType": "Personal", "givenName": "Josee", "familyName": "Dupuis" }, { "name": "Karpe, Fredrik", "nameType": "Personal", "givenName": "Fredrik", "familyName": "Karpe" }, { "name": "Groop, Leif", "nameType": "Personal", "givenName": "Leif", "familyName": "Groop" }, { "name": "Laakso, Markku", "nameType": "Personal", "givenName": "Markku", "familyName": "Laakso" }, { "name": "Pedersen, Oluf", "nameType": "Personal", "givenName": "Oluf", "familyName": "Pedersen" }, { "name": "Florez, Jose C", "nameType": "Personal", "givenName": "Jose C", "familyName": "Florez" }, { "name": "Morris, Andrew P", "nameType": "Personal", "givenName": "Andrew P", "familyName": "Morris" }, { "name": "Altshuler, David", "nameType": "Personal", "givenName": "David", "familyName": "Altshuler" }, { "name": "Meigs, James B", "nameType": "Personal", "givenName": "James B", "familyName": "Meigs" }, { "name": "Boehnke, Michael", "nameType": "Personal", "givenName": "Michael", "familyName": "Boehnke" }, { "name": "McCarthy, Mark I", "nameType": "Personal", "givenName": "Mark I", "familyName": "McCarthy" }, { "name": "Lindgren, Cecilia M", "nameType": "Personal", "givenName": "Cecilia M", "familyName": "Lindgren" }, { "name": "Gloyn, Anna L", "nameType": "Personal", "givenName": "Anna L", "familyName": "Gloyn" }, { "name": "T2D-GENES, Consortium", "nameType": "Personal", "givenName": "Consortium", "familyName": "T2D-GENES" }], "titles": [{ "title": "Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus." }], "publisher": "Apollo - University of Cambridge Repository (staging)", "container": {}, "publicationYear": 2015, "subjects": [{ "subject": "T2D-GENES consortium and GoT2D consortium" }, { "subject": "Humans" }, { "subject": "Diabetes Mellitus, Type 2" }, { "subject": "Insulin" }, { "subject": "Glucose-6-Phosphatase" }, { "subject": "Blood Glucose" }, { "subject": "Receptors, Glucagon" }, { "subject": "Glycemic Index" }, { "subject": "Gene Frequency" }, { "subject": "Polymorphism, Single Nucleotide" }, { "subject": "Genome-Wide Association Study" }, { "subject": "Exome" }, { "subject": "Glucagon-Like Peptide-1 Receptor" }], "contributors": [{ "name": "Apollo-University Of Cambridge Repository (Staging)" }, { "name": "Apollo-University Of Cambridge Repository (Staging)" }], "dates": [{ "date": "2016-09-09", "dateType": "Issued" }, { "date": "2016-09-09", "dateType": "Available" }, { "date": "2015-01-27", "dateType": "Issued" }], "language": "en", "types": { "ris": "RPRT", "bibtex": "article", "citeproc": "article-journal", "schemaOrg": "ScholarlyArticle", "resourceType": "Article", "resourceTypeGeneral": "Text" }, "relatedIdentifiers": [], "sizes": [], "formats": [], "version": null, "rightsList": [], "descriptions": [{ "description": "Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contribute substantially to unexplained genetic variance. To test this, we analyzed exome-array data from up to 33,231 non-diabetic individuals of European ancestry. We found exome-wide significant (P<5×10-7) evidence for two loci not previously highlighted by common variant GWAS: GLP1R (p.Ala316Thr, minor allele frequency (MAF)=1.5%) influencing FG levels, and URB2 (p.Glu594Val, MAF = 0.1%) influencing FI levels. Coding variant associations can highlight potential effector genes at (non-coding) GWAS signals. At the G6PC2/ABCB11 locus, we identified multiple coding variants in G6PC2 (p.Val219Leu, p.His177Tyr, and p.Tyr207Ser) influencing FG levels, conditionally independent of each other and the non-coding GWAS signal. In vitro assays demonstrate that these associated coding alleles result in reduced protein abundance via proteasomal degradation, establishing G6PC2 as an effector gene at this locus. Reconciliation of single-variant associations and functional effects was only possible when haplotype phase was considered. In contrast to earlier reports suggesting that, paradoxically, glucose-raising alleles at this locus are protective against type 2 diabetes (T2D), the p.Val219Leu G6PC2 variant displayed a modest but directionally consistent association with T2D risk. Coding variant associations for glycemic traits in GWAS signals highlight PCSK1, RREB1, and ZHX3 as likely effector transcripts. These coding variant association signals do not have a major impact on the trait variance explained, but they do provide valuable biological insights.", "descriptionType": "Abstract" }], "geoLocations": [], "fundingReferences": [], "url": null, "contentUrl": null, "metadataVersion": 26, "schemaVersion": "http://datacite.org/schema/kernel-4", "source": "mds", "isActive": true, "state": "findable", "reason": null, "created": "2016-10-05T06:49:42.000Z", "registered": null, "published": "2015", "updated": "2019-01-26T08:06:01.000Z" }, "relationships": { "client": { "data": { "id": "bl.cam", "type": "clients" } } } }, { "id": "10.17863/cam.4320", "type": "dois", "attributes": { "doi": "10.17863/cam.4320", "identifiers": [{ "identifier": "https://handle.test.datacite.org/10.17863/cam.4320", "identifierType": "DOI" }, { "identifier": "2045-2322", "identifierType": "ISSN" }, { "identifier": "https://www.repository.cam.ac.uk/handle/1810/260092", "identifierType": "uri" }, { "identifier": "2045-2322", "identifierType": "EISSN" }, { "identifier": "10.1038/srep28514", "identifierType": null }], "creators": [{ "name": "Charoen, Pimphen", "nameType": "Personal", "givenName": "Pimphen", "familyName": "Charoen" }, { "name": "Nitsch, Dorothea", "nameType": "Personal", "givenName": "Dorothea", "familyName": "Nitsch" }, { "name": "Engmann, Jorgen", "nameType": "Personal", "givenName": "Jorgen", "familyName": "Engmann" }, { "name": "Shah, Tina", "nameType": "Personal", "givenName": "Tina", "familyName": "Shah" }, { "name": "White, Jonathan", "nameType": "Personal", "givenName": "Jonathan", "familyName": "White" }, { "name": "Zabaneh, Delilah", "nameType": "Personal", "givenName": "Delilah", "familyName": "Zabaneh" }, { "name": "Jefferis, Barbara", "nameType": "Personal", "givenName": "Barbara", "familyName": "Jefferis" }, { "name": "Wannamethee, Goya", "nameType": "Personal", "givenName": "Goya", "familyName": "Wannamethee" }, { "name": "Whincup, Peter", "nameType": "Personal", "givenName": "Peter", "familyName": "Whincup" }, { "name": "Mulick, Cassidy Amy", "nameType": "Personal", "givenName": "Cassidy Amy", "familyName": "Mulick" }, { "name": "Gaunt, Tom", "nameType": "Personal", "givenName": "Tom", "familyName": "Gaunt" }, { "name": "Day, Ian", "nameType": "Personal", "givenName": "Ian", "familyName": "Day" }, { "name": "McLachlan, Stela", "nameType": "Personal", "givenName": "Stela", "familyName": "McLachlan" }, { "name": "Price, Jacqueline", "nameType": "Personal", "givenName": "Jacqueline", "familyName": "Price" }, { "name": "Kumari, Meena", "nameType": "Personal", "givenName": "Meena", "familyName": "Kumari" }, { "name": "Kivimaki, Mika", "nameType": "Personal", "givenName": "Mika", "familyName": "Kivimaki" }, { "name": "Brunner, Eric", "nameType": "Personal", "givenName": "Eric", "familyName": "Brunner" }, { "name": "Langenberg, Claudia", "nameType": "Personal", "givenName": "Claudia", "familyName": "Langenberg", "nameIdentifiers": [{ "nameIdentifier": "https://orcid.org/0000-0002-5017-7344", "nameIdentifierScheme": "ORCID" }] }, { "name": "Ben-Shlomo, Yoav", "nameType": "Personal", "givenName": "Yoav", "familyName": "Ben-Shlomo" }, { "name": "Hingorani, Aroon", "nameType": "Personal", "givenName": "Aroon", "familyName": "Hingorani" }, { "name": "Whittaker, John", "nameType": "Personal", "givenName": "John", "familyName": "Whittaker" }, { "name": "Pablo, Casas Juan", "nameType": "Personal", "givenName": "Casas Juan", "familyName": "Pablo" }, { "name": "Dudbridge, Frank", "nameType": "Personal", "givenName": "Frank", "familyName": "Dudbridge" }, { "name": "UCLEB, Consortium", "nameType": "Personal", "givenName": "Consortium", "familyName": "UCLEB" }], "titles": [{ "title": "Mendelian Randomisation study of the influence of eGFR on coronary heart disease." }], "publisher": "${dspace.name}", "container": {}, "publicationYear": 2016, "subjects": [{ "subject": "UCLEB Consortium" }], "contributors": [{ "name": "${Dspace.Name}" }, { "name": "${Dspace.Name}" }], "dates": [{ "date": "2016-09-09", "dateType": "Issued" }, { "date": "2016-09-09", "dateType": "Available" }, { "date": "2016-06-24", "dateType": "Issued" }], "language": "en", "types": { "ris": "RPRT", "bibtex": "article", "citeproc": "article-journal", "schemaOrg": "ScholarlyArticle", "resourceType": "Article", "resourceTypeGeneral": "Text" }, "relatedIdentifiers": [], "sizes": [], "formats": [], "version": null, "rightsList": [{ "rights": "Attribution 4.0 International", "rightsUri": "http://creativecommons.org/licenses/by/4.0" }], "descriptions": [{ "description": "Impaired kidney function, as measured by reduced estimated glomerular filtration rate (eGFR), has been associated with increased risk of coronary heart disease (CHD) in observational studies, but it is unclear whether this association is causal or the result of confounding or reverse causation. In this study we applied Mendelian randomisation analysis using 17 genetic variants previously associated with eGFR to investigate the causal role of kidney function on CHD. We used 13,145 participants from the UCL-LSHTM-Edinburgh-Bristol (UCLEB) Consortium and 194,427 participants from the Coronary ARtery DIsease Genome-wide Replication and Meta-analysis plus Coronary Artery Disease (CARDIoGRAMplusC4D) consortium. We observed significant association of an unweighted gene score with CHD risk (odds ratio = 0.983 per additional eGFR-increasing allele, 95% CI = 0.970-0.996, p = 0.008). However, using weights calculated from UCLEB, the gene score was not associated with disease risk (p = 0.11). These conflicting results could be explained by a single SNP, rs653178, which was not associated with eGFR in the UCLEB sample, but has known pleiotropic effects that prevent us from drawing a causal conclusion. The observational association between low eGFR and increased CHD risk was not explained by potential confounders, and there was no evidence of reverse causation, therefore leaving the remaining unexplained association as an open question.", "descriptionType": "Abstract" }], "geoLocations": [], "fundingReferences": [], "url": null, "contentUrl": null, "metadataVersion": 20, "schemaVersion": "http://datacite.org/schema/kernel-4", "source": "mds", "isActive": true, "state": "findable", "reason": null, "created": "2016-10-05T06:49:43.000Z", "registered": null, "published": "2016", "updated": "2018-10-09T07:05:11.000Z" }, "relationships": { "client": { "data": { "id": "bl.cam", "type": "clients" } } } }, { "id": "10.17863/cam.4509", "type": "dois", "attributes": { "doi": "10.17863/cam.4509", "identifiers": [{ "identifier": "https://handle.test.datacite.org/10.17863/cam.4509", "identifierType": "DOI" }, { "identifier": "2325-6621", "identifierType": "ISSN" }, { "identifier": "https://www.repository.cam.ac.uk/handle/1810/260276", "identifierType": "uri" }, { "identifier": "10.17863/CAM.4509", "identifierType": "DOI" }, { "identifier": "2325-6621", "identifierType": "EISSN" }], "creators": [{ "name": "Moore, E", "nameType": "Personal", "givenName": "E", "familyName": "Moore" }, { "name": "Chatzidiakou, Evangelia", "nameType": "Personal", "givenName": "Evangelia", "familyName": "Chatzidiakou" }, { "name": "Kuku, M-O", "nameType": "Personal", "givenName": "M-O", "familyName": "Kuku" }, { "name": "Jones, Roderic", "nameType": "Personal", "givenName": "Roderic", "familyName": "Jones", "nameIdentifiers": [{ "nameIdentifier": "https://orcid.org/0000-0002-6761-3966", "nameIdentifierScheme": "ORCID" }] }, { "name": "Smeeth, L", "nameType": "Personal", "givenName": "L", "familyName": "Smeeth" }, { "name": "Beevers, S", "nameType": "Personal", "givenName": "S", "familyName": "Beevers" }, { "name": "Kelly, FJ", "nameType": "Personal", "givenName": "FJ", "familyName": "Kelly" }, { "name": "Barratt, B", "nameType": "Personal", "givenName": "B", "familyName": "Barratt" }, { "name": "Quint, J", "nameType": "Personal", "givenName": "J", "familyName": "Quint" }], "titles": [{ "title": "Global Associations between Air Pollutants and Chronic Obstructive Pulmonary Disease Hospitalizations: A Systematic Review." }], "publisher": "Apollo - University of Cambridge Repository (staging)", "container": {}, "publicationYear": 2016, "subjects": [], "contributors": [{ "name": "Apollo-University Of Cambridge Repository (Staging)" }, { "name": "Apollo-University Of Cambridge Repository (Staging)" }], "dates": [{ "date": "2016-09-21", "dateType": "Issued" }, { "date": "2016-09-21", "dateType": "Available" }, { "date": "2016-10-01", "dateType": "Issued" }], "language": "en", "types": { "ris": "RPRT", "bibtex": "article", "citeproc": "article-journal", "schemaOrg": "ScholarlyArticle", "resourceType": "Article", "resourceTypeGeneral": "Text" }, "relatedIdentifiers": [], "sizes": [], "formats": [], "version": null, "rightsList": [], "descriptions": [{ "description": "BACKGROUND: Exacerbations are key events in Chronic Obstructive Pulmonary Disease (COPD), affecting lung function decline and quality of life. The effect of exposure to different air pollutants on COPD exacerbations is not clear. OBJECTIVE: To carry out a systematic review examining associations between air pollutants and hospital admissions for COPD exacerbations. DATA SOURCES: MEDLINE, EMBASE, BIOSIS & Science Citation Index, and the Air Pollution Epidemiology Database were searched from 1980 until September 2015. DATA EXTRACTION: Inclusion criteria focused on studies presenting solely a COPD outcome defined by hospital admissions, and a measure of gaseous air pollutants and particle fractions. The association between each pollutant with COPD admissions was investigated in metaanalyses using random-effects models. Analyses were stratified by geographical clusters to investigate the consistency of the evidence worldwide. SYNTHESIS: 46 studies were included and results for all the pollutants under investigation showed marginal positive associations; however the number of included studies was small with high heterogeneity between them and there was evidence of small-study bias. Geographical clustering of the effects of pollution on COPD hospital admissions was evident and reduced heterogeneity significantly. CONCLUSIONS: The most consistent associations was between a 1mg/m3 increase in carbon monoxide levels with COPD related admissions; Odds Ratio: 1.02 (95%CI: 1.01-1.03). The heterogeneity was moderate and there was a consistent positive association in both Europe and North America, although levels were clearly below WHO guideline values. There is mixed evidence on the effects of environmental pollution on COPD exacerbations. Limitations of previous studies included the low spatiotemporal resolution of pollutants, inadequate control for confounding factors, and the use of aggregated health data that ignore personal characteristics. The need for more targeted exposure estimates in a large number of geographical locations is evident.", "descriptionType": "Abstract" }, { "description": "This research was funded by the Medical Research Council (MR/L019744/1).", "descriptionType": "Other" }], "geoLocations": [], "fundingReferences": [], "url": null, "contentUrl": null, "metadataVersion": 24, "schemaVersion": "http://datacite.org/schema/kernel-4", "source": "mds", "isActive": true, "state": "findable", "reason": null, "created": "2016-10-05T06:49:45.000Z", "registered": null, "published": "2016", "updated": "2019-01-26T08:10:45.000Z" }, "relationships": { "client": { "data": { "id": "bl.cam", "type": "clients" } } } }, { "id": "10.17863/cam.4217", "type": "dois", "attributes": { "doi": "10.17863/cam.4217", "identifiers": [{ "identifier": null, "identifierType": "DOI" }], "creators": [], "titles": [], "publisher": null, "container": {}, "publicationYear": null, "subjects": [], "contributors": [], "dates": [], 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