Vandeleest, Jessica Beisner, Brianne Hannibal, Darcy Nathman, Amy Capitanio, John Fushing, Hsieh Atwill, Edward McCowan, Brenda DataONE 2016 Social Status Inflammation Nonhuman primate Vandeleest, Jessica National Institutes of Health. Select a sub-organization https://cran.r-project.org/web/packages/Perc/index.html https://doi.org/10.7717/peerj.2394 Dataset 47635 Creative Commons Public Domain Dedication (CC0) Although a wealth of literature points to the importance of social factors on health, a detailed understanding of the complex interplay between social and biological systems is lacking. Social status is one aspect of social life that is made up of multiple structural (humans: income, education; animals: mating system, dominance rank) and relational components (perceived social status, dominance interactions). In a nonhuman primate model we use novel network techniques to decouple two components of social status, dominance rank (a commonly used measure of social status in animal models) and dominance certainty (the relative certainty vs. ambiguity of an individual’s status), allowing for a more complex examination of how social status impacts health. Data include subject ID, demographics, social status indicators, and select health outcomes. Behavioral observations to calculate dominance rank and certainty were conducted on three outdoor captive groups of rhesus macaques (N=252 subjects), each group was observed for 5-7 weeks. Dominance rank and certainty were calculated using the Perc package in R (Fujii et al., 2015) using a network-based approach. Subjects’ general physical health (diarrhea) was assessed twice weekly and from these data, we counted the total frequency of bouts of diarrhea per subject across the 5-7 week observation period. Blood was drawn once to assess biomarkers of inflammation (interleukin-6, tumor necrosis factor-alpha, and C-reactive protein). Due to the large number of animals, blood was collected in batches of ~15 samples, this variable is described in the present dataset as SamplingOrder. Serum levels of IL-6 and TNF-α were measured using commercially available, species specific Milliplex multi-analyte profiling (MAP) reagents purchased from EMD / Millipore (Billerica, MA), and utilizing Luminex Xmap technology (Luminex, Austin, TX). Concentrations of CRP were determined using a latex particle immunoturbidmetric method on the Beckman Coulter AU480 clinical chemistry analyzer. Additional methodology is available in Vandeleest, Beisner et al. (2016). R01-HD068335 & P51-OD01107-53