--- http_interactions: - request: method: get uri: https://api.crossref.org/works/10.1155/2012/291294 body: encoding: UTF-8 string: '' headers: Connection: - close Host: - api.crossref.org User-Agent: - http.rb/5.1.1 response: status: code: 200 message: OK headers: Date: - Sun, 12 Mar 2023 22:21:10 GMT Content-Type: - application/json Transfer-Encoding: - chunked Access-Control-Expose-Headers: - Link Access-Control-Allow-Headers: - X-Requested-With, Accept, Accept-Encoding, Accept-Charset, Accept-Language, Accept-Ranges, Cache-Control Access-Control-Allow-Origin: - "*" Server: - Jetty(9.4.40.v20210413) X-Ratelimit-Limit: - '50' X-Ratelimit-Interval: - 1s X-Api-Pool: - public X-Rate-Limit-Limit: - '50' X-Rate-Limit-Interval: - 1s Permissions-Policy: - interest-cohort=() Connection: - close body: encoding: UTF-8 string: '{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T21:53:57Z","timestamp":1672869237883},"reference-count":27,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"Objective<\/jats:italic>. To find a statistically significant separation point for the QuantiFERON Gold In-Tube (QFT) interferon gamma release assay that could define an optimal \u201cretesting zone\u201d for use in serially tested low-risk populations who have test \u201creversions\u201d from initially positive to subsequently negative results.Method<\/jats:italic>. Using receiver operating characteristic analysis (ROC) to analyze retrospective data collected from 3 major hospitals, we searched for predictors of reversion until statistically significant separation points were revealed. A confirmatory regression analysis was performed on an additional sample.Results<\/jats:italic>. In 575 initially positive US healthcare workers (HCWs), 300 (52.2%) had reversions, while 275 (47.8%) had two sequential positive tests. The most statistically significant (Kappa\u2009=\u20090.48, chi-square\u2009=\u2009131.0,P<\/mml:mi><<\/mml:mo>0.001<\/mml:mn><\/mml:mrow><\/mml:math>) separation point identified by the ROC for predicting reversion was the tuberculosis antigen minus-nil (TBag-nil) value at 1.11 International Units per milliliter (IU\/mL). The second separation point was found at TBag-nil at 0.72\u2009IU\/mL (Kappa\u2009=\u20090.16, chi-square\u2009=\u20098.2,P<\/mml:mi><<\/mml:mo>0.01<\/mml:mn><\/mml:mrow><\/mml:math>). The model was validated by the regression analysis of 287\u2009HCWs.Conclusion<\/jats:italic>. Reversion likelihood increases as the TBag-nil approaches the manufacturer''s cut-point of 0.35\u2009IU\/mL. The most statistically significant separation point between those who test repeatedly positive and those who revert is 1.11\u2009IU\/mL. Clinicians should retest low-risk individuals with initial QFT results\u2009<\u20091.11\u2009IU\/mL.<\/jats:p>","DOI":"10.1155\/2012\/291294","type":"journal-article","created":{"date-parts":[[2012,12,30]],"date-time":"2012-12-30T21:05:01Z","timestamp":1356901501000},"page":"1-7","source":"Crossref","is-referenced-by-count":30,"title":["Delineating a Retesting Zone Using Receiver Operating Characteristic Analysis on Serial QuantiFERON Tuberculosis Test Results in US Healthcare Workers"],"prefix":"10.1155","volume":"2012","author":[{"given":"Wendy","family":"Thanassi","sequence":"first","affiliation":[{"name":"Department of Medicine, Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue MC-, Palo Alto, CA 94304-1207, USA"},{"name":"Occupational Health Strategic Health Care Group, Office of Public Health, Veterans Health Administration, Washington, DC 20006, USA"},{"name":"Division of Emergency Medicine, Stanford University School of Medicine, Stanford, CA 94304, 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