Abstract
Background
The association between lobular breast cancer and family history is not clear. The aim of the study was to possibly identifying new hereditary patterns predisposing for cancer in the different histopathologic subtypes of breast cancer, with focus on patients with lobular breast cancer and cancer in their first degree relatives.
Methods
In 1676 consecutive breast cancer patients detailed family history of cancer was related to histopathologic subtype of breast cancer.
Results
Patients with lobular breast cancer were found to be significantly positively associated with having a father diagnosed with cancer, OR 2.17 (95% confidence interval (CI) 1.37-3.46). The finding persisted after excluding breast cancer in the family. Ductal breast cancer was associated with having a mother diagnosed with cancer. There was a significant association between lobular breast cancer and having a father with prostate cancer, OR 2.4 (CI 1.1-5.3). The occurrence of having a father with prostate cancer for lobular breast cancer patients was higher in the younger patient group, OR 2.9 (CI 1.1-7.8), and was still high but lost statistical significance in the older patient group, OR 1.9 (CI 0.5-7.4). The association between lobular breast cancer and a father remained significant after excluding fathers with prostate cancer, OR 1.94 (CI 1.20-3.14). Other commonly occurring tumor types in the father included sarcoma and leukemia.
Conclusion
We propose that lobular breast cancer is associated with having a father diagnosed with cancer, most commonly prostate carcinoma. Since the association remained after excluding family history of breast cancer, the association seems independent of classical breast cancer heredity. The association with a father diagnosed with cancer also remained after removing prostate cancer, indicating an independence from prostate cancer as well. The reason for this association is genetically unclear, but could involve sex-specific imprinting.
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Mills"}, {"name": "Barbara-Ann Guinn"}], "month": "8", "link": [{"url": "http://www.la-press.com/infrequent-expression-of-the-cancer-testis-antigen-pasd1-in-ovarian-ca-article-a5005", "type": "fulltext", "content_type": "html"}], "year": "2015", "end_page": "38", "subject": [{"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. Including cancer and carcinogens", "scheme": "LCC"}]}, "created_date": "2015-08-25T02:30:15Z"}, {"last_updated": "2015-04-22T03:54:10Z", "id": "c0e1a6cb7dbb4e57b633c1563b3c4987", "bibjson": {"identifier": [{"type": "pissn", "id": "1000-467X"}, {"type": "eissn", "id": "1944-446X"}, {"type": "doi", "id": "10.5732/cjc.014.10116"}], "start_page": "369", "title": " Large-scale molecular characterization and analysis of gastric cancer", "journal": {"publisher": "Cancer Center,Sun Yat-sen University", "language": ["English"], "title": "Chinese Journal of Cancer", "country": "CN", "number": "8", "volume": "33"}, "author": [{"name": "Ilya Shmulevich"}], "month": "8", "link": [{"url": "\n http://www.cjcsysu.com/abstract.asp?fr=doaj&idno=21115", "type": "fulltext", "content_type": "pdf"}], "year": "2014", "subject": [{"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. Including cancer and carcinogens", "scheme": "LCC"}, {"code": "RC31-1245", "term": "Internal medicine", "scheme": "LCC"}, {"code": "R", "term": "Medicine", "scheme": "LCC"}], "end_page": "370"}, "created_date": "2014-09-30T10:00:02Z"}, {"last_updated": "2015-04-22T03:05:35Z", "id": "823bf5d81e5d4693b21990899f4e09b8", "bibjson": {"identifier": [{"type": "pissn", "id": "1000-467X"}, {"type": "eissn", "id": "1944-446X"}, {"type": "doi", "id": "10.5732/cjc.014.10117"}], "start_page": "469", "title": " TCGA divides gastric cancer into four molecular subtypes: implications for individualized therapeutics", "journal": {"publisher": "Cancer Center,Sun Yat-sen University", "language": ["English"], "title": "Chinese Journal of Cancer", "country": "CN", "number": "10", "volume": "33"}, "author": [{"name": "Wei Zhang"}], "month": "10", "link": [{"url": "\n http://www.cjcsysu.com/abstract.asp?fr=doaj&idno=21116", "type": "fulltext", "content_type": "pdf"}], "year": "2014", "subject": [{"code": "RC254-282", "term": "Neoplasms. 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Recent genomic and molecular characterization of gastric cancer, especially the findings reported by the Cancer Genome Atlas (TCGA), have shed light on the heterogeneity and potential targeted therapeutics for four different subtypes of gastric cancer.", "end_page": "470"}, "created_date": "2014-09-30T10:00:12Z"}, {"last_updated": "2015-04-22T04:13:41Z", "id": "da6d367e9f8e4b82aa9413f36485adb3", "bibjson": {"identifier": [{"type": "doi", "id": "10.5732/cjc.013.10018"}, {"type": "pissn", "id": "1000-467X"}, {"type": "eissn", "id": "1944-446X"}], "start_page": "106", "title": "The incidences and mortalities of major cancers in China, 2009", "journal": {"publisher": "Sun Yat-sen University Cancer Center", "language": ["English"], "title": "Chinese Journal of Cancer", "country": "CN", "number": "3", "volume": "32"}, "author": [{"name": "Wanqing Chen"}, {"name": "Rongshou Zheng"}, {"name": "Siwei Zhang"}, {"name": "Ping Zhao"}, {"name": "Guanglin Li"}, {"name": "Lingyou Wu"}, {"name": "Jie He"}], "month": "03", "link": [{"url": "http://www.cjcsysu.com/abstract.asp?idno=20517", "type": "fulltext"}], "year": "2013", "keywords": ["Cancer registry", "incidence", "mortality", "epidemiology", "China"], "subject": [{"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. Including cancer and carcinogens", "scheme": "LCC"}, {"code": "RC31-1245", "term": "Internal medicine", "scheme": "LCC"}, {"code": "R", "term": "Medicine", "scheme": "LCC"}, {"term": "Oncology", "scheme": "DOAJ"}, {"term": "Medicine (General)", "scheme": "DOAJ"}, {"term": "Health Sciences", "scheme": "DOAJ"}, {"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. Including cancer and carcinogens", "scheme": "LCC"}, {"code": "RC31-1245", "term": "Internal medicine", "scheme": "LCC"}, {"code": "R", "term": "Medicine", "scheme": "LCC"}, {"term": "Oncology", "scheme": "DOAJ"}, {"term": "Medicine (General)", "scheme": "DOAJ"}, {"term": "Health Sciences", "scheme": "DOAJ"}, {"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. Including cancer and carcinogens", "scheme": "LCC"}, {"code": "RC31-1245", "term": "Internal medicine", "scheme": "LCC"}, {"code": "R", "term": "Medicine", "scheme": "LCC"}, {"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. Including cancer and carcinogens", "scheme": "LCC"}, {"code": "RC31-1245", "term": "Internal medicine", "scheme": "LCC"}, {"code": "R", "term": "Medicine", "scheme": "LCC"}, {"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. Including cancer and carcinogens", "scheme": "LCC"}, {"code": "RC31-1245", "term": "Internal medicine", "scheme": "LCC"}, {"code": "R", "term": "Medicine", "scheme": "LCC"}], "abstract": "In 2012, the National Central Cancer Registry (NCCR) of China collected cancer registration information for the year 2009 from local cancer registries and analyzed it to describe the incidences and mortalities of cancers in China. Based on the data quality criteria from NCCR, data from 104 registries covering 85,470,522 people (57,489,009 in urban areas and 27,981,513 in rural areas) were checked and evaluated. The data from 72 registries were qualified and accepted for the cancer registry annual report in 2012. The total cancer incident cases and cancer deaths were 244,366 and 154,310, respectively. The morphologically verified cases accounted for 67.23%, and 3.14% of the incident cases only had information from death certifications. The crude incidence in the Chinese cancer registration areas was 285.91/100,000 (317.97/100,000 in males and 253.09/100,000 in females). The age-standardized rates for incidences based on the Chinese standard population (ASRIC) and the world standard population (ASRIW) were 146.87/100,000 and 191.72/100,000, respectively, with a cumulative incidence of 22.08%. The cancer mortality in the Chinese cancer registration areas was 180.54/100,000 (224.20/100,000 in males and 135.85/100,000 in females). The age-standardized rates for mortalities based on the Chinese standard population(ASRMC) and the world standard population (ASRMW) were 85.06/100,000 and 115.65/100,000, respectively, and the cumulative mortality was 12.94%. Lung cancer, gastric cancer, colorectal cancer, liver cancer, esophageal cancer, pancreatic cancer, encephaloma, lymphoma, female breast cancer, and cervical cancer were the most common cancers, accounting for 75% of all cancer cases. Lung cancer, gastric cancer, liver cancer, esophageal cancer, colorectal cancer, pancreatic cancer, breast cancer, encephaloma, leukemia, and lymphoma accounted for 80% of all cancer deaths. The cancer registration''s population coverage has been increasing, and its data quality is improving. As the basis of the cancer control program, the cancer registry plays an important role in directing anticancer strategies in the medium and long term. Because cancer burdens are different in urban and rural areas in China, prevention and control efforts should be based on practical situations. ", "end_page": "112"}, "created_date": "2013-03-19T08:31:56Z"}, {"last_updated": "2015-04-22T03:15:55Z", "id": "8f79f8dcc5bf4b789a97a2cc67ff6da5", "bibjson": {"identifier": [{"type": "doi", "id": "10.5732/cjc.011.10444"}, {"type": "pissn", "id": "1000-467X"}, {"type": "eissn", "id": "1944-446X"}], "start_page": "564", "title": "A new prospect in cancer therapy: targeting cancer stem cells to eradicate cancer", "journal": {"publisher": "Sun Yat-sen University Cancer Center", "language": ["English"], "title": "Chinese Journal of Cancer", "country": "CN", "number": "12", "volume": "31"}, "author": [{"name": "Yi-Min Zhu"}, {"name": "Li-Hua Yuan"}, {"name": "Ke-Feng Pu"}, {"name": "Bing Dong"}, {"name": "An-Xin Wang"}, {"name": "Li-Sha Chen"}], "month": "12", "link": [{"url": "http://www.cjcsysu.com/abstract.asp?fr=doaj&idno=20081", "type": "fulltext"}], "year": "2012", "subject": [{"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. 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Including cancer and carcinogens", "scheme": "LCC"}, {"code": "RC31-1245", "term": "Internal medicine", "scheme": "LCC"}, {"code": "R", "term": "Medicine", "scheme": "LCC"}, {"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. Including cancer and carcinogens", "scheme": "LCC"}, {"code": "RC31-1245", "term": "Internal medicine", "scheme": "LCC"}, {"code": "R", "term": "Medicine", "scheme": "LCC"}], "abstract": "According to the cancer stem cell theory, cancers can be initiated by cancer stem cells. This makes cancer stem cells prime targets for therapeutic intervention. Eradicating cancer stem cells by efficient targeting agents may have the potential to cure cancer. In this review, we summarize recent breakthroughs that have improved our understanding of cancer stem cells, and we discuss the therapeutic strategy of targeting cancer stem cells, a promising future direction for cancer stem cell research.", "end_page": "572"}, "created_date": "2013-04-26T10:30:03Z"}, {"last_updated": "2015-04-22T03:51:28Z", "id": "bd4c138833f54e558052765bada05514", "bibjson": {"identifier": [{"type": "pissn", "id": "1837-9664"}], "start_page": "107", "title": "Human Cancer Classification: A Systems Biology- Based Model Integrating Morphology, Cancer Stem Cells, Proteomics, and Genomics", "journal": {"publisher": "Ivyspring International Publisher", "language": ["English"], "license": [{"type": "CC BY-NC-ND", "title": "CC BY-NC-ND"}], "title": "Journal of Cancer", "country": "AU", "number": "1", "volume": "2"}, "author": [{"name": "Halliday A Idikio"}], "link": [{"url": "http://www.jcancer.org/v02p0107.htm", "type": "fulltext"}], "year": "2011", "subject": [{"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. Including cancer and carcinogens", "scheme": "LCC"}, {"code": "RC31-1245", "term": "Internal medicine", "scheme": "LCC"}, {"code": "R", "term": "Medicine", "scheme": "LCC"}, {"term": "Oncology", "scheme": "DOAJ"}, {"term": "Medicine (General)", "scheme": "DOAJ"}, {"term": "Health Sciences", "scheme": "DOAJ"}, {"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. Including cancer and carcinogens", "scheme": "LCC"}, {"code": "RC31-1245", "term": "Internal medicine", "scheme": "LCC"}, {"code": "R", "term": "Medicine", "scheme": "LCC"}, {"term": "Oncology", "scheme": "DOAJ"}, {"term": "Medicine (General)", "scheme": "DOAJ"}, {"term": "Health Sciences", "scheme": "DOAJ"}, {"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. Including cancer and carcinogens", "scheme": "LCC"}, {"code": "RC31-1245", "term": "Internal medicine", "scheme": "LCC"}, {"code": "R", "term": "Medicine", "scheme": "LCC"}, {"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. Including cancer and carcinogens", "scheme": "LCC"}, {"code": "RC31-1245", "term": "Internal medicine", "scheme": "LCC"}, {"code": "R", "term": "Medicine", "scheme": "LCC"}, {"code": "RC254-282", "term": "Neoplasms. Tumors. Oncology. Including cancer and carcinogens", "scheme": "LCC"}, {"code": "RC31-1245", "term": "Internal medicine", "scheme": "LCC"}, {"code": "R", "term": "Medicine", "scheme": "LCC"}], "abstract": "Human cancer classification is currently based on the idea of cell of origin, light and electron microscopic attributes of the cancer. What is not yet integrated into cancer classification are the functional attributes of these cancer cells. Recent innovative techniques in biology have provided a wealth of information on the genomic, transcriptomic and proteomic changes in cancer cells. The emergence of the concept of cancer stem cells needs to be included in a classification model to capture the known attributes of cancer stem cells and their potential contribution to treatment response, and metastases. The integrated model of cancer classification presented here incorporates all morphology, cancer stem cell contributions, genetic, and functional attributes of cancer. Integrated cancer classification models could eliminate the unclassifiable cancers as used in current classifications. Future cancer treatment may be advanced by using an integrated model of cancer classification.
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